Medical polyacrylate pressure sensitive adhesive for all seasons without side effects

At present, the medical pressure-sensitive adhesive on the market is made by the reaction of monomer, solvent, and initiator. The monomer is acrylic acid, methyl methacrylate, butyl methacrylate, and other acrylates, the solvent is ethyl acetate, and the initiator is peroxide. This medical pressure-sensitive adhesive is irritating to human skin and even produces allergic reactions.

The purpose of this paper is to provide a kind of polyacrylate pressure-sensitive adhesive suitable for all seasons without side effects and its preparation method. Here’s how we did it: butyl acrylate, isooctyl acrylate. Vinyl acetate is the monomer, ethyl acetate is the solvent, and peroxide is the initiator, after purification treatment, by weight percentage polymer composition is: butyl acrylate 50~70% isoctyl acrylate 7~15%, vinyl acetate 15~35%, peroxide is the monomer total 0.4~1.0%, Ethyl acetate 53~65% of the total weight by percentage by weight One component of the polymer: butyl acrylate 70%, isooctyl acrylate 10%, vinyl acetate 20%, peroxide 0.7% of the total monomer, ethyl acetate 55% of the total weight by percentage by weight another component of the polymer: butyl acrylate 60%, Isooctyl acrylate was 9% and vinyl acetate was 30%. Peroxides are 0.76% of the total monomer: and ethyl acetate is 56% of the total weight. Peroxides mainly refer to benzoyl peroxide and azobisisobutyronitrile.

This is dedicated to the manufacture of the medical polyacrylate pressure-sensitive adhesive method, the steps are (1) monomer, solvent, and initiator mixing evenly;

(2) Most of the mixture was placed in the drip funnel, and the remaining small part of the mixture was placed in the reactor to fill the reactor with nitrogen to drive out air; After the reactor stirred at reflux temperature for 20~40 minutes, the mixture in the drip funnel was dropped into the continuously stirred reactor within 60~120 minutes.

(3) Then slowly add the solvent containing initiator into the reactor, and continue stirring the reaction at reflux temperature for 20~40 minutes:

(4) Add the solvent slowly in the reactor, continue to stir, and react at reflux temperature for 20~40 minutes, and then at atmospheric pressure, the added solvent is distilled off, and the gel liquid is cooled.

The pressure-sensitive adhesive made above is a colorless or light yellow transparent viscous liquid, with the smell of ester, non-toxic to human skin, has no irritation, and no allergic reaction, and is a good performance of skin external auxiliary materials, main uses: used for skin patch, such as a variety of drug preparations around the adhesive, the fixed adhesive of the ECG electrode, etc.; It is used to make drug-controlled release patches mixed with some drugs. It not only has a good adhesive effect to ensure close contact between drugs and skin but also controls the dose of drugs entering the human body through the skin through the special chemical structure and composition of this pressure-sensitive adhesive, so as to achieve the purpose of zero-order drug release.