Hot melt pressure sensitive adhesive type percutaneous medication patch

Transdermal medicated patch, also known as “plaster”, is a kind of external use of traditional Chinese medicine. It is made of vegetable oil or animal oil and boiled into a gelatinous substance. It is applied on the side of cloth, paper or skin and can be pasted on the affected area for a long time, mainly used for treating boils and relieving swelling and pain. Black plaster has the effect of reducing swelling, removing poison, relieving pain and promoting blood circulation.

It is an important part of traditional chinese medicine, western medicine and orthopedics, and is widely used in clinic. The medicine in the plaster is directly pasted on the body surface acupoints, the property through the fur from the surface into the subcutaneous tissue, on the one hand, the relative advantage of the concentration of the drug in the local, on the other hand, through the operation of the meridians, direct to the disease of the zang fu organ disorder of Qi disorder, play the drug “return to the meridian” and functional effect, so as to give full play to the maximum systemic pharmacological effect.

However, in addition to damaging nerve, blood vessel, muscle and other tissues and intestinal reactions, traditional injection and oral therapy is not easy for patients to accept, and these methods are easy to make drugs through the whole body’s blood circulation and intestinal damage, and few drugs actually reach the local area of the disease, so the amount of drugs used is very large, and the targeted effect is poor. The external treatment of plaster completely solves this problem.

The drug acts directly on the affected area, making the efficacy several times higher, and is not easy to produce drug resistance. Nowadays, most drugs are taken orally, and the market of percutaneous patches drug release fast, high cost, poor effect, low cure rate, obvious side effects. Pressure sensitive adhesive is the key material of transdermal drug delivery patch. It is usually dissolved in organic solvent before coating, which has the problems of environmental pollution and high energy consumption. The rapid development of emulsion pressure sensitive adhesive in recent years is also limited by slow drying speed, emulsifier migration and other problems. Hot melt pressure sensitive adhesive is thermoplastic polymer as the main body of the pressure sensitive adhesive, in the molten state coating, do not need to use organic solvents.

It has the advantages of low pollution, fast coating speed and so on. It is widely used in packaging, medical and health. It has been found that hot melt pressure sensitive adhesive has good compatibility with lipophilic drugs and fast release speed, so it is expected to be the material of this kind of drug patch.