Advantages of hydrophilic adhesives

Hydrophilic adhesives usually have the following advantages:

• hydrophilic adhesive and hydrophobic adhesive can provide greater adhesion, because of the affinity

The surface energy of water-based adhesives is generally higher and closer to that of biological substrates such as skin and mucous membranes.

• Hydrophilic adhesives are compatible with a wide range of drugs, excipients, and additives.
• The plasticizing effect of the water absorbed by the hydrophilic adhesive from the hydrated skin or mucous tissue can be enhanced

Adhesion, as opposed to hydrophobic adhesives.

• The increased solubility of the drug in the hydrophilic adhesive helps to control the drug release kinetics.
• Use a hydrophilic adhesive based on a hydrophilic polymer, which can extend the level of adhesion – cohesion. The ability to control and manipulate

• The binding properties of hydrophilic polymers are much less sensitive to their molecular weight than hydrophobic polymers

This is caused by specific intramolecular and intermolecular interactions within the hydrophilic binder.

Hydrophobic PSA can be prepared by adding a non-viscous hydrophilic polymer and filler to a hydrophobic adhesive.

Class “hydrophilic” and improve the hydrophilicity of the adhesive composition, for example, Polyisobutene (PIB)PSA is hydrated by adding cellulose and cellulose derivatives (US Patent 4231369), polyvinyl alcohol (PVA), pectin and gelatin (US patents Ns4367732 and 4867748), and silica (US patent N5643187). Rubber binders can also be administratively modified by filling them with amphoteric surfactants, or by treating PSA polymers with plasma 30 oxygen discharge. Acrylic PSA can be hydrophilic by adding PVP (US patent N5645855). Although hydrophilic treatment of hydrophobic adhesive has some effect, it will lead to a partial loss of adhesion.

Therefore, there is a need for a new hydrophilic adhesive composition suitable for a wide range of applications, such as locally applied drug delivery systems, which can meet all of the above criteria and provide an effective drug release rate for any active agent, whether hydrophilic, ionic or lipophilic.