Prior art of pressure sensitive adhesives for medical use

In general, pressure-sensitive adhesive coating products (such as pressure-sensitive adhesive strips and pressure-sensitive adhesive sheets) have been widely used in building materials, home appliances, automotive cushioning materials, crack-filling materials, etc. Typical forms of these pressure-sensitive adhesive strips and sheets include double-sided coated tape with a pressure-sensitive adhesive layer on two opposite surfaces of the substrate, foam tape with a pressure-sensitive adhesive layer on at least one surface of the foam substrate, commonly used pressure-sensitive adhesive tape with a pressure-sensitive adhesive layer on one surface of the appropriate substrate, etc.

In the medical field, medical adhesive materials that have a pressure-sensitive adhesive layer containing drugs on the substrate are widely used. The other has drug-free pressure sensitivity on at least one surface of the soft sheet or tape substrate.

The adhesive layer of medical adhesive materials, such as adhesive bandages and so on the above used for various pressure-sensitive adhesive coating products and medical adhesive materials in the most representative is the main acrylic copolymer solvent-based pressure-sensitive adhesive, this is because solvent acrylic pressure-sensitive adhesive has weather resistance, durability, heat resistance, frost resistance and water resistance and other excellent performance. Solvent-based acrylic pressure-sensitive adhesives are also widely used as pressure-sensitive adhesives to form pressure-sensitive adhesive layers in medical bonding materials because their physical properties (including adhesion strength) can be obtained by mixing each.

Acrylic monomers of one type are easy to control. The acrylic pressure-sensitive adhesive can be generally through solution or emulsion polymerization of the main group is divided into (methyl) acrylic acid alkyl cool monomer composition, to the polymer solution to add additives, and then dry to remove the solvent, when the preparation of medical adhesive materials, the required drugs in the drying solvent before adding to the polymer solution.

In medical use, the use of a transdermal absorbent medical adhesive material containing nitroglycerin for the treatment or prevention of cardiac diseases such as angina, myocardial infarction, or heart failure). For example, in the Japanese patent Disclosure No.Sho63-246325, a nitroglycerin-containing adhesive material using a specific (methyl) acrylic alkyl copolymer is revealed.

Transdermal preparations using medical pressure-sensitive adhesives containing copolymers of (methyl) alkyl acrylate and vinylpyrrolidone in the above acrylic pressure-sensitive adhesives are known to show the efficacy of the active component for a short time after application and for a longer period of time (Japanese Patent Publication No. Hei 3-70685).