Pressure-sensitive adhesive is a hydrophilic polymer

Pressure-sensitive adhesives are well known and have been used for many years in a variety of industrial, consumer, and medical applications. Pressure-sensitive adhesives are typically viscous and adhere instantly when applied to the substrate. A variety of polymers have been used to make pressure-sensitive adhesives, such as acrylic and methacrylate homopolymers or copolymers, butyl rubber-based systems, polysiloxane, polyester, ethyl ester, ethyl amide, olefin copolymer materials, natural or synthetic rubber, etc. All Psas are elastomers, that is, they exhibit the characteristic viscoelasticity of rubber.

Pressure-sensitive adhesives are widely used in percutaneous drug delivery devices or “patches” that adhere to skin or mucous tissue at the time of use. The adhesion, transport, storage, and biological properties of various cohesive compounds form the basis for their application in percutaneous drug delivery systems, as described below:

High viscosity with the best-sliding adhesion transition point:

The drug release dynamics are controlled by the rate of transdermal drug delivery and the operating life of the device:

A drug whose compatibility and efficiency remain stable with the addition of related drugs:

Biological properties: No toxicity, no irritation, or sensitization to the skin.

Such diversity is difficult to combine into a single system.

Examples of pressure-sensitive adhesives that have been suggested for use in percutaneous delivery systems include polysiloxane

30(e.g., polydimethylsiloxane, polyphenyl siloxane, and siloxane mixtures), polyisobutene, polyacrylates, acrylate-acrylate copolymers (e.g., copolymers of acrylic acid with 2-ethylhexyl acrylate or isoctylacrylate), And viscous rubber such as polyisobutene, polybutadiene, polystyrene-isoprene copolymer, polystyrene-butadiene copolymer, and chloroprene (diene) rubber (polychloroprene). All of these Ps are hydrophilic polymers. They have the common disadvantage of losing adhesion to hydrate substrates.